Since Pirfenidone is metabolised in the CYP1A2 enzyme pathway, any drug which inhibits this enzyme is probably going to precipitate the toxicity of pirfenidone: concomitant therapy should be to be averted.
phenobarbital will reduce the level or outcome of pirfenidone by affecting hepatic enzyme C
Large doses or lengthy-term utilization of paliperidone could cause a significant movement ailment that may not be reversible. The extended you use paliperidone, the more possible you might be to establish this problem, especially if you're a woman or an more mature adult.
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